9 skills found
kegge13 / BistroMathA general Radiotherapy profile and depth dose analysis tool
Novartis / TATTranscriptomics-to-Activity Transformer (TAT) is a deep learning model to predict compound bioactivity in a dose-response assay using compound-induced transcriptomic profiles over concentration.
hillaryhusband / PkmeFlexible framework package for solving linear systems of ordinary differential equations for PBPK and PK type models
amalyutina / CSSWe proposed a novel experimental design to enable a more cost-effective testing of synergy and sensitivity for a drug pair. First, the dose-response curve for each single drug is determined. Then the drug at its IC50 concentration is combined with the other drug at multiple doses, generating an IC50-based dose-response curve for the drug pair. We developed a drug combination sensitivi-ty score (CSS) to summarize the dose-response curves. Using high-throughput drug combination data from cancer cell lines, we showed that the CSS is highly reproducible among the replicates. With machine learning approaches such as elastic net, random forests and support vector ma-chines, the CSS can also be predicted at high accuracy using features including drug-target in-teraction profiles and structural fingerprints. Furthermore, we derived a synergy score based on the difference between the drug combination and the single drug dose-response curves. We showed that the CSS-based synergy score is able to detect true synergistic and antagonistic drug combinations. The IC50-based experimental design coupled with the CSS scoring facilitated the evaluation of drug combination sensitivity and synergy using the same unit, with minimal ex-perimental material that is required to achieve sufficient prediction accuracy. The experimental and computational strategy could be utilized as an efficient platform for improving the discovery rate in high-throughput drug combination screening.
afg1 / SOBPtoolsA couple of python scripts I wrote to produce spread out bragg peak profiles in 2D (i.e. depth-dose curves)
kingrpaul / DoseproDose Profile Utility
Amdh-sys / SPK Kinerja Dosen Profile Matchingaplikasi sistem pendukung keputusan penilaian kinerja dosen mengajar secara daring menggunakan metode profile matching
iTReX-Shiny / ITReXiTReX is a web based Shiny application for interactive exploration of mono- and combination therapy dose response profiling data and drug target interaction network mapping.
oustling / Dta1dProgram can be used in radiotherapy departments by physicists to perform some QA procedures. Program compares two dose profiles. Calculated in treatment planning system Monaco from Elekta and measured in water phantom by IBA OmniPro Accept.
