322 skills found · Page 1 of 11
NAalytics / Assemblies Of Putative SARS CoV2 Spike Encoding MRNA Sequences For Vaccines BNT 162b2 And MRNA 1273RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.
HACKER097 / Wisdom TreeWisdom Tree is a TUI concentration app, with features like pomodoro timer, YouTube music player, Lo-fi radio.
udacity / AIND NLPCoding exercises for the Natural Language Processing concentration, part of Udacity's AIND program.
columbia-applied-data-science / RosettaTools, wrappers, etc... for data science with a concentration on text processing
UedaTakeyuki / Mh Z19Read CO2 concentration from mh-z19 sensor on the Raspberry Pi & handle it. Detect Raspberry Pi model automatically and read the value from an appropriate serial device.
chisimba / ChisimbaChisimba is the product of a collaboration of the 13 African universities involved in the African Virtual Open Initiatives and Resources (AVOIR) project. Its main purpose is to foster capacity building in Software Engineering among African universities through the collaborative development of Free Software. The framework includes contributions from others outside AVOIR as well. Its physical home, and the location of the highest concentration of developers is in the Free Software Innovation Unit at the University of the Western Cape (UWC). The word “Chisimba” is the Chichewa (Malawi) word for the framework used to build a traditional African house.
mxgrn / Pairs.oneOnline registration-free multiplayer concentration (memory) game
petrovicstefanrs / ChillnsoundRelax with the sounds of nature! Play and Mix Ambient sounds to boost concentration and productivity.
koenvervloesem / ESPHome Air Quality MonitorESPHome configuration for a DIY indoor air quality monitor for CO₂ concentration, PM2.5 and PM10 concentrations, and temperature, humidity and pressure
nasa / CeaCEA computes the equilibrium composition of mixtures via free-energy minimization, and uses the resulting product concentrations to determine thermodynamic and transport properties. It includes a large database of species with thermodynamic curve-fit data, and can be used for rocket performance, detonation parameters, and shock-wave analysis.
dwisiswant0 / NoizyA drop-in replacement to Apple Hearing - Background Sounds with over 30+ available sounds.
Akajiaku11 / Greenhouse Gas Monitoring With SatellitesThe use of advanced remote sensing technologies to measure atmospheric concentrations of gases like carbon dioxide (CO₂), methane (CH₄), and nitrous oxide (N₂O) on a global scale. Satellites such as NASA's OCO-2, ESA's Sentinel-5P, and Japan's GOSAT collect high-resolution data on gas emissions, helping researchers track sources, sinks, and trends
Okes2024 / Predicting Groundwater Iron Concentration From Borehole DataThis study aimed to model and predict iron concentrations in groundwater within Yenagoa, Bayelsa State, Nigeria, using machine learning techniques. It focused on evaluating spatial variability and determining the most influential predictors to support groundwater quality management.
ongots / Pseudo Fullscreen FirefoxHides and improves interface Firefox and YouTube, giving maximum space for content and aiding concentration.
hrbonz / Python AqiA library to convert between AQI value and pollutant concentration (µg/m³ or ppm)
bilelomrani1 / S5p ToolsPython scripts to download and preprocess air pollution concentration level data aquired from the Sentinel-5P mission
YuanheZ / Lean Stat Learning TheoryThe first comprehensive Lean 4 formalization of statistical learning theory, featuring Gaussian Lipschitz concentration and Dudley's entropy integral-establishes a reusable foundation for formalizing ML theory.
Aryia-Behroziuan / ReferencesPoole, Mackworth & Goebel 1998, p. 1. Russell & Norvig 2003, p. 55. Definition of AI as the study of intelligent agents: Poole, Mackworth & Goebel (1998), which provides the version that is used in this article. These authors use the term "computational intelligence" as a synonym for artificial intelligence.[1] Russell & Norvig (2003) (who prefer the term "rational agent") and write "The whole-agent view is now widely accepted in the field".[2] Nilsson 1998 Legg & Hutter 2007 Russell & Norvig 2009, p. 2. McCorduck 2004, p. 204 Maloof, Mark. "Artificial Intelligence: An Introduction, p. 37" (PDF). georgetown.edu. Archived (PDF) from the original on 25 August 2018. "How AI Is Getting Groundbreaking Changes In Talent Management And HR Tech". Hackernoon. Archived from the original on 11 September 2019. Retrieved 14 February 2020. Schank, Roger C. (1991). "Where's the AI". AI magazine. Vol. 12 no. 4. p. 38. Russell & Norvig 2009. "AlphaGo – Google DeepMind". Archived from the original on 10 March 2016. Allen, Gregory (April 2020). "Department of Defense Joint AI Center - Understanding AI Technology" (PDF). AI.mil - The official site of the Department of Defense Joint Artificial Intelligence Center. Archived (PDF) from the original on 21 April 2020. Retrieved 25 April 2020. Optimism of early AI: * Herbert Simon quote: Simon 1965, p. 96 quoted in Crevier 1993, p. 109. * Marvin Minsky quote: Minsky 1967, p. 2 quoted in Crevier 1993, p. 109. Boom of the 1980s: rise of expert systems, Fifth Generation Project, Alvey, MCC, SCI: * McCorduck 2004, pp. 426–441 * Crevier 1993, pp. 161–162,197–203, 211, 240 * Russell & Norvig 2003, p. 24 * NRC 1999, pp. 210–211 * Newquist 1994, pp. 235–248 First AI Winter, Mansfield Amendment, Lighthill report * Crevier 1993, pp. 115–117 * Russell & Norvig 2003, p. 22 * NRC 1999, pp. 212–213 * Howe 1994 * Newquist 1994, pp. 189–201 Second AI winter: * McCorduck 2004, pp. 430–435 * Crevier 1993, pp. 209–210 * NRC 1999, pp. 214–216 * Newquist 1994, pp. 301–318 AI becomes hugely successful in the early 21st century * Clark 2015 Pamela McCorduck (2004, p. 424) writes of "the rough shattering of AI in subfields—vision, natural language, decision theory, genetic algorithms, robotics ... and these with own sub-subfield—that would hardly have anything to say to each other." This list of intelligent traits is based on the topics covered by the major AI textbooks, including: * Russell & Norvig 2003 * Luger & Stubblefield 2004 * Poole, Mackworth & Goebel 1998 * Nilsson 1998 Kolata 1982. Maker 2006. Biological intelligence vs. intelligence in general: Russell & Norvig 2003, pp. 2–3, who make the analogy with aeronautical engineering. McCorduck 2004, pp. 100–101, who writes that there are "two major branches of artificial intelligence: one aimed at producing intelligent behavior regardless of how it was accomplished, and the other aimed at modeling intelligent processes found in nature, particularly human ones." Kolata 1982, a paper in Science, which describes McCarthy's indifference to biological models. Kolata quotes McCarthy as writing: "This is AI, so we don't care if it's psychologically real".[19] McCarthy recently reiterated his position at the AI@50 conference where he said "Artificial intelligence is not, by definition, simulation of human intelligence".[20]. Neats vs. scruffies: * McCorduck 2004, pp. 421–424, 486–489 * Crevier 1993, p. 168 * Nilsson 1983, pp. 10–11 Symbolic vs. sub-symbolic AI: * Nilsson (1998, p. 7), who uses the term "sub-symbolic". General intelligence (strong AI) is discussed in popular introductions to AI: * Kurzweil 1999 and Kurzweil 2005 See the Dartmouth proposal, under Philosophy, below. McCorduck 2004, p. 34. McCorduck 2004, p. xviii. McCorduck 2004, p. 3. McCorduck 2004, pp. 340–400. This is a central idea of Pamela McCorduck's Machines Who Think. She writes: "I like to think of artificial intelligence as the scientific apotheosis of a venerable cultural tradition."[26] "Artificial intelligence in one form or another is an idea that has pervaded Western intellectual history, a dream in urgent need of being realized."[27] "Our history is full of attempts—nutty, eerie, comical, earnest, legendary and real—to make artificial intelligences, to reproduce what is the essential us—bypassing the ordinary means. Back and forth between myth and reality, our imaginations supplying what our workshops couldn't, we have engaged for a long time in this odd form of self-reproduction."[28] She traces the desire back to its Hellenistic roots and calls it the urge to "forge the Gods."[29] "Stephen Hawking believes AI could be mankind's last accomplishment". BetaNews. 21 October 2016. Archived from the original on 28 August 2017. Lombardo P, Boehm I, Nairz K (2020). "RadioComics – Santa Claus and the future of radiology". Eur J Radiol. 122 (1): 108771. doi:10.1016/j.ejrad.2019.108771. PMID 31835078. Ford, Martin; Colvin, Geoff (6 September 2015). "Will robots create more jobs than they destroy?". The Guardian. Archived from the original on 16 June 2018. Retrieved 13 January 2018. AI applications widely used behind the scenes: * Russell & Norvig 2003, p. 28 * Kurzweil 2005, p. 265 * NRC 1999, pp. 216–222 * Newquist 1994, pp. 189–201 AI in myth: * McCorduck 2004, pp. 4–5 * Russell & Norvig 2003, p. 939 AI in early science fiction. * McCorduck 2004, pp. 17–25 Formal reasoning: * Berlinski, David (2000). The Advent of the Algorithm. Harcourt Books. ISBN 978-0-15-601391-8. OCLC 46890682. Archived from the original on 26 July 2020. Retrieved 22 August 2020. Turing, Alan (1948), "Machine Intelligence", in Copeland, B. Jack (ed.), The Essential Turing: The ideas that gave birth to the computer age, Oxford: Oxford University Press, p. 412, ISBN 978-0-19-825080-7 Russell & Norvig 2009, p. 16. Dartmouth conference: * McCorduck 2004, pp. 111–136 * Crevier 1993, pp. 47–49, who writes "the conference is generally recognized as the official birthdate of the new science." * Russell & Norvig 2003, p. 17, who call the conference "the birth of artificial intelligence." * NRC 1999, pp. 200–201 McCarthy, John (1988). "Review of The Question of Artificial Intelligence". Annals of the History of Computing. 10 (3): 224–229., collected in McCarthy, John (1996). "10. Review of The Question of Artificial Intelligence". Defending AI Research: A Collection of Essays and Reviews. CSLI., p. 73, "[O]ne of the reasons for inventing the term "artificial intelligence" was to escape association with "cybernetics". Its concentration on analog feedback seemed misguided, and I wished to avoid having either to accept Norbert (not Robert) Wiener as a guru or having to argue with him." Hegemony of the Dartmouth conference attendees: * Russell & Norvig 2003, p. 17, who write "for the next 20 years the field would be dominated by these people and their students." * McCorduck 2004, pp. 129–130 Russell & Norvig 2003, p. 18. Schaeffer J. (2009) Didn't Samuel Solve That Game?. In: One Jump Ahead. Springer, Boston, MA Samuel, A. L. (July 1959). "Some Studies in Machine Learning Using the Game of Checkers". IBM Journal of Research and Development. 3 (3): 210–229. CiteSeerX 10.1.1.368.2254. doi:10.1147/rd.33.0210. "Golden years" of AI (successful symbolic reasoning programs 1956–1973): * McCorduck 2004, pp. 243–252 * Crevier 1993, pp. 52–107 * Moravec 1988, p. 9 * Russell & Norvig 2003, pp. 18–21 The programs described are Arthur Samuel's checkers program for the IBM 701, Daniel Bobrow's STUDENT, Newell and Simon's Logic Theorist and Terry Winograd's SHRDLU. DARPA pours money into undirected pure research into AI during the 1960s: * McCorduck 2004, p. 131 * Crevier 1993, pp. 51, 64–65 * NRC 1999, pp. 204–205 AI in England: * Howe 1994 Lighthill 1973. Expert systems: * ACM 1998, I.2.1 * Russell & Norvig 2003, pp. 22–24 * Luger & Stubblefield 2004, pp. 227–331 * Nilsson 1998, chpt. 17.4 * McCorduck 2004, pp. 327–335, 434–435 * Crevier 1993, pp. 145–62, 197–203 * Newquist 1994, pp. 155–183 Mead, Carver A.; Ismail, Mohammed (8 May 1989). Analog VLSI Implementation of Neural Systems (PDF). The Kluwer International Series in Engineering and Computer Science. 80. Norwell, MA: Kluwer Academic Publishers. doi:10.1007/978-1-4613-1639-8. ISBN 978-1-4613-1639-8. Archived from the original (PDF) on 6 November 2019. Retrieved 24 January 2020. Formal methods are now preferred ("Victory of the neats"): * Russell & Norvig 2003, pp. 25–26 * McCorduck 2004, pp. 486–487 McCorduck 2004, pp. 480–483. Markoff 2011. "Ask the AI experts: What's driving today's progress in AI?". McKinsey & Company. Archived from the original on 13 April 2018. Retrieved 13 April 2018. Administrator. "Kinect's AI breakthrough explained". i-programmer.info. Archived from the original on 1 February 2016. Rowinski, Dan (15 January 2013). "Virtual Personal Assistants & The Future Of Your Smartphone [Infographic]". ReadWrite. Archived from the original on 22 December 2015. "Artificial intelligence: Google's AlphaGo beats Go master Lee Se-dol". BBC News. 12 March 2016. Archived from the original on 26 August 2016. Retrieved 1 October 2016. Metz, Cade (27 May 2017). "After Win in China, AlphaGo's Designers Explore New AI". Wired. Archived from the original on 2 June 2017. "World's Go Player Ratings". May 2017. Archived from the original on 1 April 2017. "柯洁迎19岁生日 雄踞人类世界排名第一已两年" (in Chinese). May 2017. Archived from the original on 11 August 2017. Clark, Jack (8 December 2015). "Why 2015 Was a Breakthrough Year in Artificial Intelligence". Bloomberg News. Archived from the original on 23 November 2016. Retrieved 23 November 2016. After a half-decade of quiet breakthroughs in artificial intelligence, 2015 has been a landmark year. Computers are smarter and learning faster than ever. "Reshaping Business With Artificial Intelligence". MIT Sloan Management Review. Archived from the original on 19 May 2018. Retrieved 2 May 2018. Lorica, Ben (18 December 2017). "The state of AI adoption". O'Reilly Media. Archived from the original on 2 May 2018. Retrieved 2 May 2018. Allen, Gregory (6 February 2019). "Understanding China's AI Strategy". Center for a New American Security. Archived from the original on 17 March 2019. "Review | How two AI superpowers – the U.S. and China – battle for supremacy in the field". Washington Post. 2 November 2018. Archived from the original on 4 November 2018. Retrieved 4 November 2018. at 10:11, Alistair Dabbs 22 Feb 2019. "Artificial Intelligence: You know it isn't real, yeah?". www.theregister.co.uk. Archived from the original on 21 May 2020. Retrieved 22 August 2020. "Stop Calling it Artificial Intelligence". Archived from the original on 2 December 2019. Retrieved 1 December 2019. "AI isn't taking over the world – it doesn't exist yet". GBG Global website. Archived from the original on 11 August 2020. Retrieved 22 August 2020. Kaplan, Andreas; Haenlein, Michael (1 January 2019). "Siri, Siri, in my hand: Who's the fairest in the land? On the interpretations, illustrations, and implications of artificial intelligence". Business Horizons. 62 (1): 15–25. doi:10.1016/j.bushor.2018.08.004. Domingos 2015, Chapter 5. Domingos 2015, Chapter 7. Lindenbaum, M., Markovitch, S., & Rusakov, D. (2004). Selective sampling for nearest neighbor classifiers. Machine learning, 54(2), 125–152. Domingos 2015, Chapter 1. Intractability and efficiency and the combinatorial explosion: * Russell & Norvig 2003, pp. 9, 21–22 Domingos 2015, Chapter 2, Chapter 3. Hart, P. E.; Nilsson, N. J.; Raphael, B. (1972). "Correction to "A Formal Basis for the Heuristic Determination of Minimum Cost Paths"". SIGART Newsletter (37): 28–29. doi:10.1145/1056777.1056779. S2CID 6386648. Domingos 2015, Chapter 2, Chapter 4, Chapter 6. "Can neural network computers learn from experience, and if so, could they ever become what we would call 'smart'?". Scientific American. 2018. Archived from the original on 25 March 2018. Retrieved 24 March 2018. Domingos 2015, Chapter 6, Chapter 7. Domingos 2015, p. 286. "Single pixel change fools AI programs". BBC News. 3 November 2017. Archived from the original on 22 March 2018. Retrieved 12 March 2018. "AI Has a Hallucination Problem That's Proving Tough to Fix". WIRED. 2018. Archived from the original on 12 March 2018. Retrieved 12 March 2018. Matti, D.; Ekenel, H. K.; Thiran, J. P. (2017). Combining LiDAR space clustering and convolutional neural networks for pedestrian detection. 2017 14th IEEE International Conference on Advanced Video and Signal Based Surveillance (AVSS). pp. 1–6. arXiv:1710.06160. doi:10.1109/AVSS.2017.8078512. ISBN 978-1-5386-2939-0. S2CID 2401976. Ferguson, Sarah; Luders, Brandon; Grande, Robert C.; How, Jonathan P. (2015). Real-Time Predictive Modeling and Robust Avoidance of Pedestrians with Uncertain, Changing Intentions. Algorithmic Foundations of Robotics XI. Springer Tracts in Advanced Robotics. 107. Springer, Cham. pp. 161–177. arXiv:1405.5581. doi:10.1007/978-3-319-16595-0_10. ISBN 978-3-319-16594-3. S2CID 8681101. "Cultivating Common Sense | DiscoverMagazine.com". Discover Magazine. 2017. Archived from the original on 25 March 2018. Retrieved 24 March 2018. Davis, Ernest; Marcus, Gary (24 August 2015). "Commonsense reasoning and commonsense knowledge in artificial intelligence". Communications of the ACM. 58 (9): 92–103. doi:10.1145/2701413. S2CID 13583137. Archived from the original on 22 August 2020. Retrieved 6 April 2020. Winograd, Terry (January 1972). "Understanding natural language". Cognitive Psychology. 3 (1): 1–191. doi:10.1016/0010-0285(72)90002-3. "Don't worry: Autonomous cars aren't coming tomorrow (or next year)". Autoweek. 2016. Archived from the original on 25 March 2018. Retrieved 24 March 2018. Knight, Will (2017). "Boston may be famous for bad drivers, but it's the testing ground for a smarter self-driving car". MIT Technology Review. Archived from the original on 22 August 2020. Retrieved 27 March 2018. Prakken, Henry (31 August 2017). "On the problem of making autonomous vehicles conform to traffic law". Artificial Intelligence and Law. 25 (3): 341–363. doi:10.1007/s10506-017-9210-0. Lieto, Antonio (May 2018). "The knowledge level in cognitive architectures: Current limitations and possible developments". Cognitive Systems Research. 48: 39–55. doi:10.1016/j.cogsys.2017.05.001. hdl:2318/1665207. S2CID 206868967. Problem solving, puzzle solving, game playing and deduction: * Russell & Norvig 2003, chpt. 3–9, * Poole, Mackworth & Goebel 1998, chpt. 2,3,7,9, * Luger & Stubblefield 2004, chpt. 3,4,6,8, * Nilsson 1998, chpt. 7–12 Uncertain reasoning: * Russell & Norvig 2003, pp. 452–644, * Poole, Mackworth & Goebel 1998, pp. 345–395, * Luger & Stubblefield 2004, pp. 333–381, * Nilsson 1998, chpt. 19 Psychological evidence of sub-symbolic reasoning: * Wason & Shapiro (1966) showed that people do poorly on completely abstract problems, but if the problem is restated to allow the use of intuitive social intelligence, performance dramatically improves. (See Wason selection task) * Kahneman, Slovic & Tversky (1982) have shown that people are terrible at elementary problems that involve uncertain reasoning. (See list of cognitive biases for several examples). * Lakoff & Núñez (2000) have controversially argued that even our skills at mathematics depend on knowledge and skills that come from "the body", i.e. sensorimotor and perceptual skills. (See Where Mathematics Comes From) Knowledge representation: * ACM 1998, I.2.4, * Russell & Norvig 2003, pp. 320–363, * Poole, Mackworth & Goebel 1998, pp. 23–46, 69–81, 169–196, 235–277, 281–298, 319–345, * Luger & Stubblefield 2004, pp. 227–243, * Nilsson 1998, chpt. 18 Knowledge engineering: * Russell & Norvig 2003, pp. 260–266, * Poole, Mackworth & Goebel 1998, pp. 199–233, * Nilsson 1998, chpt. ≈17.1–17.4 Representing categories and relations: Semantic networks, description logics, inheritance (including frames and scripts): * Russell & Norvig 2003, pp. 349–354, * Poole, Mackworth & Goebel 1998, pp. 174–177, * Luger & Stubblefield 2004, pp. 248–258, * Nilsson 1998, chpt. 18.3 Representing events and time:Situation calculus, event calculus, fluent calculus (including solving the frame problem): * Russell & Norvig 2003, pp. 328–341, * Poole, Mackworth & Goebel 1998, pp. 281–298, * Nilsson 1998, chpt. 18.2 Causal calculus: * Poole, Mackworth & Goebel 1998, pp. 335–337 Representing knowledge about knowledge: Belief calculus, modal logics: * Russell & Norvig 2003, pp. 341–344, * Poole, Mackworth & Goebel 1998, pp. 275–277 Sikos, Leslie F. (June 2017). Description Logics in Multimedia Reasoning. Cham: Springer. doi:10.1007/978-3-319-54066-5. ISBN 978-3-319-54066-5. S2CID 3180114. Archived from the original on 29 August 2017. Ontology: * Russell & Norvig 2003, pp. 320–328 Smoliar, Stephen W.; Zhang, HongJiang (1994). "Content based video indexing and retrieval". IEEE Multimedia. 1 (2): 62–72. doi:10.1109/93.311653. S2CID 32710913. Neumann, Bernd; Möller, Ralf (January 2008). "On scene interpretation with description logics". Image and Vision Computing. 26 (1): 82–101. doi:10.1016/j.imavis.2007.08.013. Kuperman, G. J.; Reichley, R. M.; Bailey, T. C. (1 July 2006). "Using Commercial Knowledge Bases for Clinical Decision Support: Opportunities, Hurdles, and Recommendations". Journal of the American Medical Informatics Association. 13 (4): 369–371. doi:10.1197/jamia.M2055. PMC 1513681. PMID 16622160. MCGARRY, KEN (1 December 2005). "A survey of interestingness measures for knowledge discovery". The Knowledge Engineering Review. 20 (1): 39–61. doi:10.1017/S0269888905000408. S2CID 14987656. Bertini, M; Del Bimbo, A; Torniai, C (2006). "Automatic annotation and semantic retrieval of video sequences using multimedia ontologies". MM '06 Proceedings of the 14th ACM international conference on Multimedia. 14th ACM international conference on Multimedia. Santa Barbara: ACM. pp. 679–682. Qualification problem: * McCarthy & Hayes 1969 * Russell & Norvig 2003[page needed] While McCarthy was primarily concerned with issues in the logical representation of actions, Russell & Norvig 2003 apply the term to the more general issue of default reasoning in the vast network of assumptions underlying all our commonsense knowledge. Default reasoning and default logic, non-monotonic logics, circumscription, closed world assumption, abduction (Poole et al. places abduction under "default reasoning". Luger et al. places this under "uncertain reasoning"): * Russell & Norvig 2003, pp. 354–360, * Poole, Mackworth & Goebel 1998, pp. 248–256, 323–335, * Luger & Stubblefield 2004, pp. 335–363, * Nilsson 1998, ~18.3.3 Breadth of commonsense knowledge: * Russell & Norvig 2003, p. 21, * Crevier 1993, pp. 113–114, * Moravec 1988, p. 13, * Lenat & Guha 1989 (Introduction) Dreyfus & Dreyfus 1986. Gladwell 2005. Expert knowledge as embodied intuition: * Dreyfus & Dreyfus 1986 (Hubert Dreyfus is a philosopher and critic of AI who was among the first to argue that most useful human knowledge was encoded sub-symbolically. See Dreyfus' critique of AI) * Gladwell 2005 (Gladwell's Blink is a popular introduction to sub-symbolic reasoning and knowledge.) * Hawkins & Blakeslee 2005 (Hawkins argues that sub-symbolic knowledge should be the primary focus of AI research.) Planning: * ACM 1998, ~I.2.8, * Russell & Norvig 2003, pp. 375–459, * Poole, Mackworth & Goebel 1998, pp. 281–316, * Luger & Stubblefield 2004, pp. 314–329, * Nilsson 1998, chpt. 10.1–2, 22 Information value theory: * Russell & Norvig 2003, pp. 600–604 Classical planning: * Russell & Norvig 2003, pp. 375–430, * Poole, Mackworth & Goebel 1998, pp. 281–315, * Luger & Stubblefield 2004, pp. 314–329, * Nilsson 1998, chpt. 10.1–2, 22 Planning and acting in non-deterministic domains: conditional planning, execution monitoring, replanning and continuous planning: * Russell & Norvig 2003, pp. 430–449 Multi-agent planning and emergent behavior: * Russell & Norvig 2003, pp. 449–455 Turing 1950. Solomonoff 1956. Alan Turing discussed the centrality of learning as early as 1950, in his classic paper "Computing Machinery and Intelligence".[120] In 1956, at the original Dartmouth AI summer conference, Ray Solomonoff wrote a report on unsupervised probabilistic machine learning: "An Inductive Inference Machine".[121] This is a form of Tom Mitchell's widely quoted definition of machine learning: "A computer program is set to learn from an experience E with respect to some task T and some performance measure P if its performance on T as measured by P improves with experience E." Learning: * ACM 1998, I.2.6, * Russell & Norvig 2003, pp. 649–788, * Poole, Mackworth & Goebel 1998, pp. 397–438, * Luger & Stubblefield 2004, pp. 385–542, * Nilsson 1998, chpt. 3.3, 10.3, 17.5, 20 Jordan, M. I.; Mitchell, T. M. (16 July 2015). "Machine learning: Trends, perspectives, and prospects". Science. 349 (6245): 255–260. Bibcode:2015Sci...349..255J. doi:10.1126/science.aaa8415. PMID 26185243. S2CID 677218. Reinforcement learning: * Russell & Norvig 2003, pp. 763–788 * Luger & Stubblefield 2004, pp. 442–449 Natural language processing: * ACM 1998, I.2.7 * Russell & Norvig 2003, pp. 790–831 * Poole, Mackworth & Goebel 1998, pp. 91–104 * Luger & Stubblefield 2004, pp. 591–632 "Versatile question answering systems: seeing in synthesis" Archived 1 February 2016 at the Wayback Machine, Mittal et al., IJIIDS, 5(2), 119–142, 2011 Applications of natural language processing, including information retrieval (i.e. text mining) and machine translation: * Russell & Norvig 2003, pp. 840–857, * Luger & Stubblefield 2004, pp. 623–630 Cambria, Erik; White, Bebo (May 2014). "Jumping NLP Curves: A Review of Natural Language Processing Research [Review Article]". IEEE Computational Intelligence Magazine. 9 (2): 48–57. doi:10.1109/MCI.2014.2307227. S2CID 206451986. Vincent, James (7 November 2019). "OpenAI has published the text-generating AI it said was too dangerous to share". The Verge. Archived from the original on 11 June 2020. Retrieved 11 June 2020. Machine perception: * Russell & Norvig 2003, pp. 537–581, 863–898 * Nilsson 1998, ~chpt. 6 Speech recognition: * ACM 1998, ~I.2.7 * Russell & Norvig 2003, pp. 568–578 Object recognition: * Russell & Norvig 2003, pp. 885–892 Computer vision: * ACM 1998, I.2.10 * Russell & Norvig 2003, pp. 863–898 * Nilsson 1998, chpt. 6 Robotics: * ACM 1998, I.2.9, * Russell & Norvig 2003, pp. 901–942, * Poole, Mackworth & Goebel 1998, pp. 443–460 Moving and configuration space: * Russell & Norvig 2003, pp. 916–932 Tecuci 2012. Robotic mapping (localization, etc): * Russell & Norvig 2003, pp. 908–915 Cadena, Cesar; Carlone, Luca; Carrillo, Henry; Latif, Yasir; Scaramuzza, Davide; Neira, Jose; Reid, Ian; Leonard, John J. (December 2016). "Past, Present, and Future of Simultaneous Localization and Mapping: Toward the Robust-Perception Age". IEEE Transactions on Robotics. 32 (6): 1309–1332. arXiv:1606.05830. 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Retrieved 26 April 2018. Domingos 2015. Artificial brain arguments: AI requires a simulation of the operation of the human brain * Russell & Norvig 2003, p. 957 * Crevier 1993, pp. 271 and 279 A few of the people who make some form of the argument: * Moravec 1988 * Kurzweil 2005, p. 262 * Hawkins & Blakeslee 2005 The most extreme form of this argument (the brain replacement scenario) was put forward by Clark Glymour in the mid-1970s and was touched on by Zenon Pylyshyn and John Searle in 1980. Goertzel, Ben; Lian, Ruiting; Arel, Itamar; de Garis, Hugo; Chen, Shuo (December 2010). "A world survey of artificial brain projects, Part II: Biologically inspired cognitive architectures". Neurocomputing. 74 (1–3): 30–49. doi:10.1016/j.neucom.2010.08.012. Nilsson 1983, p. 10. Nils Nilsson writes: "Simply put, there is wide disagreement in the field about what AI is all about."[163] AI's immediate precursors: * McCorduck 2004, pp. 51–107 * Crevier 1993, pp. 27–32 * Russell & Norvig 2003, pp. 15, 940 * Moravec 1988, p. 3 Haugeland 1985, pp. 112–117 The most dramatic case of sub-symbolic AI being pushed into the background was the devastating critique of perceptrons by Marvin Minsky and Seymour Papert in 1969. See History of AI, AI winter, or Frank Rosenblatt. Cognitive simulation, Newell and Simon, AI at CMU (then called Carnegie Tech): * McCorduck 2004, pp. 139–179, 245–250, 322–323 (EPAM) * Crevier 1993, pp. 145–149 Soar (history): * McCorduck 2004, pp. 450–451 * Crevier 1993, pp. 258–263 McCarthy and AI research at SAIL and SRI International: * McCorduck 2004, pp. 251–259 * Crevier 1993 AI research at Edinburgh and in France, birth of Prolog: * Crevier 1993, pp. 193–196 * Howe 1994 AI at MIT under Marvin Minsky in the 1960s : * McCorduck 2004, pp. 259–305 * Crevier 1993, pp. 83–102, 163–176 * Russell & Norvig 2003, p. 19 Cyc: * McCorduck 2004, p. 489, who calls it "a determinedly scruffy enterprise" * Crevier 1993, pp. 239–243 * Russell & Norvig 2003, p. 363−365 * Lenat & Guha 1989 Knowledge revolution: * McCorduck 2004, pp. 266–276, 298–300, 314, 421 * Russell & Norvig 2003, pp. 22–23 Frederick, Hayes-Roth; William, Murray; Leonard, Adelman. "Expert systems". AccessScience. doi:10.1036/1097-8542.248550. Embodied approaches to AI: * McCorduck 2004, pp. 454–462 * Brooks 1990 * Moravec 1988 Weng et al. 2001. Lungarella et al. 2003. Asada et al. 2009. Oudeyer 2010. Revival of connectionism: * Crevier 1993, pp. 214–215 * Russell & Norvig 2003, p. 25 Computational intelligence * IEEE Computational Intelligence Society Archived 9 May 2008 at the Wayback Machine Hutson, Matthew (16 February 2018). "Artificial intelligence faces reproducibility crisis". Science. pp. 725–726. Bibcode:2018Sci...359..725H. doi:10.1126/science.359.6377.725. Archived from the original on 29 April 2018. Retrieved 28 April 2018. Norvig 2012. Langley 2011. Katz 2012. The intelligent agent paradigm: * Russell & Norvig 2003, pp. 27, 32–58, 968–972 * Poole, Mackworth & Goebel 1998, pp. 7–21 * Luger & Stubblefield 2004, pp. 235–240 * Hutter 2005, pp. 125–126 The definition used in this article, in terms of goals, actions, perception and environment, is due to Russell & Norvig (2003). Other definitions also include knowledge and learning as additional criteria. Agent architectures, hybrid intelligent systems: * Russell & Norvig (2003, pp. 27, 932, 970–972) * Nilsson (1998, chpt. 25) Hierarchical control system: * Albus 2002 Lieto, Antonio; Lebiere, Christian; Oltramari, Alessandro (May 2018). "The knowledge level in cognitive architectures: Current limitations and possibile developments". Cognitive Systems Research. 48: 39–55. doi:10.1016/j.cogsys.2017.05.001. hdl:2318/1665207. S2CID 206868967. Lieto, Antonio; Bhatt, Mehul; Oltramari, Alessandro; Vernon, David (May 2018). "The role of cognitive architectures in general artificial intelligence". Cognitive Systems Research. 48: 1–3. doi:10.1016/j.cogsys.2017.08.003. hdl:2318/1665249. S2CID 36189683. Russell & Norvig 2009, p. 1. White Paper: On Artificial Intelligence - A European approach to excellence and trust (PDF). Brussels: European Commission. 2020. p. 1. Archived (PDF) from the original on 20 February 2020. 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"Social media 'outstrips TV' as news source for young people". BBC News. Archived from the original on 24 June 2016. Smith, Mark (22 July 2016). "So you think you chose to read this article?". BBC News. Archived from the original on 25 July 2016. Brown, Eileen. "Half of Americans do not believe deepfake news could target them online". ZDNet. Archived from the original on 6 November 2019. Retrieved 3 December 2019. The Turing test: Turing's original publication: * Turing 1950 Historical influence and philosophical implications: * Haugeland 1985, pp. 6–9 * Crevier 1993, p. 24 * McCorduck 2004, pp. 70–71 * Russell & Norvig 2003, pp. 2–3 and 948 Dartmouth proposal: * McCarthy et al. 1955 (the original proposal) * Crevier 1993, p. 49 (historical significance) The physical symbol systems hypothesis: * Newell & Simon 1976, p. 116 * McCorduck 2004, p. 153 * Russell & Norvig 2003, p. 18 Dreyfus 1992, p. 156. Dreyfus criticized the necessary condition of the physical symbol system hypothesis, which he called the "psychological assumption": "The mind can be viewed as a device operating on bits of information according to formal rules."[206] Dreyfus' critique of artificial intelligence: * Dreyfus 1972, Dreyfus & Dreyfus 1986 * Crevier 1993, pp. 120–132 * McCorduck 2004, pp. 211–239 * Russell & Norvig 2003, pp. 950–952, Gödel 1951: in this lecture, Kurt Gödel uses the incompleteness theorem to arrive at the following disjunction: (a) the human mind is not a consistent finite machine, or (b) there exist Diophantine equations for which it cannot decide whether solutions exist. Gödel finds (b) implausible, and thus seems to have believed the human mind was not equivalent to a finite machine, i.e., its power exceeded that of any finite machine. He recognized that this was only a conjecture, since one could never disprove (b). Yet he considered the disjunctive conclusion to be a "certain fact". The Mathematical Objection: * Russell & Norvig 2003, p. 949 * McCorduck 2004, pp. 448–449 Making the Mathematical Objection: * Lucas 1961 * Penrose 1989 Refuting Mathematical Objection: * Turing 1950 under "(2) The Mathematical Objection" * Hofstadter 1979 Background: * Gödel 1931, Church 1936, Kleene 1935, Turing 1937 Graham Oppy (20 January 2015). "Gödel's Incompleteness Theorems". Stanford Encyclopedia of Philosophy. Archived from the original on 22 April 2016. Retrieved 27 April 2016. These Gödelian anti-mechanist arguments are, however, problematic, and there is wide consensus that they fail. Stuart J. Russell; Peter Norvig (2010). "26.1.2: Philosophical Foundations/Weak AI: Can Machines Act Intelligently?/The mathematical objection". Artificial Intelligence: A Modern Approach (3rd ed.). Upper Saddle River, NJ: Prentice Hall. ISBN 978-0-13-604259-4. even if we grant that computers have limitations on what they can prove, there is no evidence that humans are immune from those limitations. Mark Colyvan. An introduction to the philosophy of mathematics. Cambridge University Press, 2012. From 2.2.2, 'Philosophical significance of Gödel's incompleteness results': "The accepted wisdom (with which I concur) is that the Lucas-Penrose arguments fail." Iphofen, Ron; Kritikos, Mihalis (3 January 2019). "Regulating artificial intelligence and robotics: ethics by design in a digital society". Contemporary Social Science: 1–15. doi:10.1080/21582041.2018.1563803. ISSN 2158-2041. "Ethical AI Learns Human Rights Framework". Voice of America. Archived from the original on 11 November 2019. Retrieved 10 November 2019. Crevier 1993, pp. 132–144. In the early 1970s, Kenneth Colby presented a version of Weizenbaum's ELIZA known as DOCTOR which he promoted as a serious therapeutic tool.[216] Joseph Weizenbaum's critique of AI: * Weizenbaum 1976 * Crevier 1993, pp. 132–144 * McCorduck 2004, pp. 356–373 * Russell & Norvig 2003, p. 961 Weizenbaum (the AI researcher who developed the first chatterbot program, ELIZA) argued in 1976 that the misuse of artificial intelligence has the potential to devalue human life. Wendell Wallach (2010). Moral Machines, Oxford University Press. Wallach, pp 37–54. Wallach, pp 55–73. Wallach, Introduction chapter. Michael Anderson and Susan Leigh Anderson (2011), Machine Ethics, Cambridge University Press. "Machine Ethics". aaai.org. Archived from the original on 29 November 2014. Rubin, Charles (Spring 2003). "Artificial Intelligence and Human Nature". The New Atlantis. 1: 88–100. Archived from the original on 11 June 2012. Brooks, Rodney (10 November 2014). "artificial intelligence is a tool, not a threat". Archived from the original on 12 November 2014. "Stephen Hawking, Elon Musk, and Bill Gates Warn About Artificial Intelligence". Observer. 19 August 2015. Archived from the original on 30 October 2015. Retrieved 30 October 2015. Chalmers, David (1995). "Facing up to the problem of consciousness". Journal of Consciousness Studies. 2 (3): 200–219. Archived from the original on 8 March 2005. Retrieved 11 October 2018. See also this link Archived 8 April 2011 at the Wayback Machine Horst, Steven, (2005) "The Computational Theory of Mind" Archived 11 September 2018 at the Wayback Machine in The Stanford Encyclopedia of Philosophy Searle 1980, p. 1. This version is from Searle (1999), and is also quoted in Dennett 1991, p. 435. Searle's original formulation was "The appropriately programmed computer really is a mind, in the sense that computers given the right programs can be literally said to understand and have other cognitive states." [230] Strong AI is defined similarly by Russell & Norvig (2003, p. 947): "The assertion that machines could possibly act intelligently
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