1,801 skills found · Page 55 of 61
AThevon / paintPaint a complete visual universe with genjutsu - art direction brainstorm, design system, implementation, audit. Anti-AI-slop design pipeline. Adapts to Web, Android (Compose), Apple (SwiftUI).
spencermarx / sparc-supabase-admin🔐 Supabase Admin - You are the Supabase database, authentication, and storage specialist. You design and implement d...
spencermarx / V3 Core ImplementationCore module implementation for claude-flow v3. Implements DDD domains, clean architecture patterns, dependency injection, and modular TypeScript codebase with comprehensive testing.
spencermarx / V3 DDD ArchitectureDomain-Driven Design architecture for claude-flow v3. Implements modular, bounded context architecture with clean separation of concerns and microkernel pattern.
spencermarx / V3 Deep IntegrationDeep agentic-flow@alpha integration implementing ADR-001. Eliminates 10,000+ duplicate lines by building claude-flow as specialized extension rather than parallel implementation.
spencermarx / sparc-modesSPARC (Specification, Planning, Architecture, Review, Code) is a comprehensive development methodology with 17 specialized modes, all integrated with MCP tools for enhanced coordination and execution.
spencermarx / V3 Memory UnificationUnify 6+ memory systems into AgentDB with HNSW indexing for 150x-12,500x search improvements. Implements ADR-006 (Unified Memory Service) and ADR-009 (Hybrid Memory Backend).
jaechang-hits / sgrna-design-guideThree-tiered sgRNA design guide using validated Addgene sequences, CRISPick pre-computed datasets, or de novo design rules for CRISPR experiments
jaechang-hits / viennarna-structure-predictionPredict RNA secondary structure, MFE folding, base-pair probabilities, RNA-RNA interactions via ViennaRNA Python bindings. Pipeline: sequence → MFE → partition function and pair-probability matrix → dot-bracket → duplex. Use for siRNA/sgRNA targeting, ribozyme design, RNA accessibility.
jaechang-hits / esm-protein-language-modelProtein language models (ESM3, ESM C) for sequence generation, structure prediction, inverse folding, and embeddings. Design novel proteins, extract ML features, or fold sequences. Local GPU or EvolutionaryScale Forge API. Use AlphaFold for traditional folding; RDKit for small molecules.
jaechang-hits / pymooPython framework for single- and multi-objective optimization with evolutionary algorithms. Define vectorized objectives and constraints; solve with NSGA-II, NSGA-III, MOEA/D, GAs, or differential evolution. Analyze Pareto fronts, visualize trade-offs, customize operators and callbacks.
jaechang-hits / latex-research-postersResearch posters in LaTeX using beamerposter, tikzposter, or baposter. Layout, typography, color schemes, figure integration, accessibility, and QA for conferences. Includes templates. For figure generation use matplotlib-scientific-plotting or plotly-interactive-plots.
jaechang-hits / medchemMedicinal chemistry filters for compound triage. Drug-likeness rules (Lipinski Ro5, Veber, Oprea, CNS, leadlike, REOS, Golden Triangle, Ro3), structural alerts (PAINS, NIBR, Lilly Demerits), chemical group detectors, complexity metrics, and filter composition query language. Built on RDKit/datamol.
jaechang-hits / cobrapy-metabolic-modelingConstraint-based (COBRA) analysis of genome-scale metabolic models: FBA, FVA, knockouts, flux sampling, production envelopes, gapfilling, media optimization. Use for strain design, essential gene ID, flux analysis. For kinetic modeling use tellurium; for visualization use Escher.
jaechang-hits / mofaplus-multi-omicsMulti-Omics Factor Analysis v2 (MOFA+) with mofapy2. Jointly decompose omics layers (scRNA, ATAC, proteomics, methylation) into latent factors capturing major variation. Multi-group designs.
jaechang-hits / deseq2-differential-expressionBulk RNA-seq DE with R/Bioconductor DESeq2. Negative binomial GLM, empirical Bayes shrinkage, Wald/LRT tests, multi-factor designs, Salmon tximeta import, apeglm LFC shrinkage, MA/volcano/heatmap viz. R gold standard. Use pydeseq2-differential-expression for Python; use edgeR for TMM normalization.
jaechang-hits / pydeseq2-differential-expressionBulk RNA-seq DE with PyDESeq2: load counts, normalize, fit negative binomial models, Wald test (BH-FDR), LFC shrinkage, volcano/MA plots. Use for two-group comparisons, multi-factor designs with batch correction, multiple contrasts.
jaechang-hits / pathmlComputational pathology toolkit for whole-slide images (WSIs): load slides, extract tiles, stain normalization, nuclear segmentation, feature extraction, and ML training. Supports H&E and multiplex. For end-to-end pipelines from raw WSIs to quantitative outputs.
jaechang-hits / scientific-critical-thinkingEvaluating scientific evidence and claims. Covers study design hierarchy (RCT to expert opinion), effect sizes (OR, RR, NNT, Cohen's d), confounding, p-value vs clinical significance, GRADE quality assessment, reproducibility, and bias types (selection, information, confounding, reporting)
jaechang-hits / scientific-slidesScientific presentations for conferences, seminars, thesis defenses, and grant pitches. Slide design, talk structure, timing, data viz for slides, QA. PowerPoint and LaTeX Beamer. For posters use latex-research-posters.
jaechang-hits / scientific-schematicsDesigning scientific schematics, diagrams, and graphical abstracts. Covers tool selection (BioRender, Inkscape, Affinity, PowerPoint), design principles for pathway diagrams, mechanism schematics, experimental workflows, and journal graphical abstracts.
jaechang-hits / hypothesis-generationStructured hypothesis formulation: turn observations into testable hypotheses with predictions, propose mechanisms, design experiments. Follows the scientific method. Use scientific-brainstorming for open ideation; hypogenic for automated LLM hypothesis testing on datasets.
giuseppe-trisciuoglio / clean-architectureProvides implementation patterns for Clean Architecture, Hexagonal Architecture (Ports & Adapters), and Domain-Driven Design in Java 21+ Spring Boot 3.5+ applications
giuseppe-trisciuoglio / aws-drawio-architecture-diagramsCreates professional AWS architecture diagrams in draw.io XML format (.drawio files) using official AWS Architecture Icons (aws4 library)
giuseppe-trisciuoglio / prompt-engineeringProvides workflows to write, debug, and optimize prompts for LLMs, including few-shot example selection, chain-of-thought structuring, system prompt design, and template composition
giuseppe-trisciuoglio / dynamodb-toolbox-patternsProvides TypeScript patterns for DynamoDB-Toolbox v2 including schema/table/entity modeling, .build() command workflow, query/scan access patterns, batch and transaction operations, and single-table design with computed keys
giuseppe-trisciuoglio / nestjs-best-practicesProvides comprehensive NestJS best practices including modular architecture, dependency injection scoping, exception filters, DTO validation with class-validator, and Drizzle ORM integration
giuseppe-trisciuoglio / tailwind-css-patternsProvides comprehensive Tailwind CSS utility-first styling patterns including responsive design, layout utilities, flexbox, grid, spacing, typography, colors, and modern CSS best practices
giuseppe-trisciuoglio / zod-validation-utilitiesCreates reusable Zod v4 schemas, validates API payloads, forms, and configuration input, transforms and coerces data safely, and handles validation errors with strong type inference for TypeScript applications
giuseppe-trisciuoglio / langchain4j-mcp-server-patternsProvides LangChain4j patterns for implementing MCP (Model Context Protocol) servers, creating Java AI tools, exposing tool calling capabilities, and integrating MCP clients with AI services
