Top Rated

Refactor and review SwiftUI view files with strong defaults for small dedicated subviews, MV-over-MVVM data flow, stable view trees, explicit dependency injection, and correct Observation usage

Build local constrained-browser agents with a safe_browser tool that owns CDP, enforces a domain allowlist with Fetch interception, and lets a runtime Claude Agent SDK agent complete browsing tasks without raw browser, shell, or CDP access

Use this skill when the user wants to search the web without a full browser session: find URLs, titles, and metadata for a query. Prefer it over a browser when you just need search results, not page content. Returns structured results with titles, URLs, authors, and dates.

Independently check whether an implementation matches its stated goal and return PASS/WARN/FAIL with actionable issues. Use for second-opinion validation of an implementation or generated output.

Build or refresh a browser-viewable topic graph over Claude session history using local clustering. Use for mapping or clustering sessions, recent or stale topic analysis, or rebuilding/showing the session graph. Unlike wiki-history-ingest, it indexes raw sessions and never writes to the vault.

Search the session-brain graph for a past agent session by topic and load the winning transcript into the current conversation. Use for finding which session handled X, when Y was last worked on, or whether this was done before. Read-only; requires a session-brain graph.

Run and operate the DeepStream Multi-View 3D Tracking reference app, also known as MV3DT

Read-only Jetson health snapshot for identity, memory, GPU, thermal, power, storage, services, and top processes.

Three.js scene setup: scenes and fog, cameras, the renderer and tone mapping, the animation loop, object hierarchies, transforms, core math and cleanup, on WebGL or with WebGPU and TSL

List, find, and show Azure resources across subscriptions or resource groups. Handles prompts like \"list the websites in my subscription\", \"list my web apps\", \"show my app services\", \"list virtual machines\", \"list my VMs\", \"show storage accounts\", \"find container apps\", and \"what reso…

Install or update the M365 Agents Toolkit (ATK) CLI and VS Code extension. Triggers: "install atk", "update atk", "install agents toolkit", "update agents toolkit", "install the toolkit", "setup atk", "get atk", "install atk cli", "install atk extension", "install atk vsix", "update the vs code exte…

Parse and analyze multiple sequence alignments using Biopython. Extract sequences, identify conserved regions, analyze gaps, work with annotations, and manipulate alignment data for downstream analysis

Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity

Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering

Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals

Identify likely causal variants within GWAS loci using SuSiE for sum of single effects regression and FINEMAP for shotgun stochastic search. Computes posterior inclusion probabilities and credible sets to prioritize variants for functional follow-up

Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics

Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality

Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values

De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomic peak data

Annotate ChIP-seq peaks to genomic features and genes using ChIPseeker. Assign peaks to promoters, exons, introns, and intergenic regions. Find nearest genes and calculate distance to TSS. Generate annotation plots and statistics

Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions

Visualize copy number profiles, segments, and compare across samples. Create publication-quality plots of CNV data from CNVkit, GATK, or other callers