LASTZ - pairwise DNA sequence aligner

This repository contains the latest official working branch of LASTZ. Official releases are tagged, and can be found in https://github.com/lastz/lastz/releases. Users are encouraged to use a tagged release, as this working branch may not be stable.

For information about installation and use, see https://lastz.github.io/lastz (equivalent to README.lastz.html in this repository).

As of this writing, the latest official release is version 1.04.52. Legacy releases — those prior to September 2021 — can be found at http://www.bx.psu.edu/~rsharris/lastz (in the form of tarballs).

The UCSC genome browser group has included lastz and lastz_D in their prebuilt binaries (the version there might lag behind the latest version here):

    http://hgdownload.soe.ucsc.edu/admin/exe/linux.x86_64/
    http://hgdownload.soe.ucsc.edu/admin/exe/macOSX.x86_64/

Two GPU accelerated versions, KegAlign and SegAlign, can be found at https://github.com/galaxyproject/KegAlign and https://github.com/gsneha26/SegAlign.

Updated Apr/2/2025 by Bob Harris (the LASTZ guy)