SolubleMPNN
Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation.
Install / Use
npx skills add aipoch/open-science --skill solublempnnInstalls into whichever agent you are using.
SKILL.md
Installable skill definition
Quality Score
Category
Development & EngineeringSupported Platforms
Our assessment of SolubleMPNN
SolubleMPNN scores 87/100 on our quality scale, 1034th of 2,569 Development & Engineering skills we index (top 41%).
We have not analysed the SKILL.md file itself yet, so the content part of this score is an estimate until our crawler reaches it.
With 4,918 GitHub stars, it is one of the more widely adopted skills in the catalogue.
Maintenance, license and trust
- The repository was last updated 2 days ago, so SolubleMPNN is actively maintained.
- It is released under the Apache-2.0 license, a permissive license that allows use, modification and commercial use with attribution.
- Its trust signals score 100/100, with no cautions. These come from repository metadata, not a code audit — read the skill file before letting an agent act on it.
SolubleMPNN compared with similar skills
All 4 of these similar skills score higher than SolubleMPNN; compare them before choosing.
| Skill | Score | Stars | Updated | Format |
|---|---|---|---|---|
| SolubleMPNN (this skill)by aipoch | 87 | 4.9k | 2d ago | SKILL.md |
| Agent-Reachby Panniantong | 100 | 85.6k | 11d ago | CLAUDE.md |
| ai-job-searchby MadsLorentzen | 100 | 44.0k | 6d ago | CLAUDE.md |
| claude-howtoby luongnv89 | 100 | 41.7k | today | CLAUDE.md |
| algorithmic-artby anthropics | 100 | 177.9k | 4d ago | SKILL.md |
Frequently asked questions
- How do I install SolubleMPNN?
- Run
npx skills add aipoch/open-science --skill SolubleMPNN. The install tabs above show the steps for each supported agent. - Which AI agents does SolubleMPNN work with?
- It is written for Universal, as a SKILL.md file. Other agents that read the same format can often use it too.
- Is SolubleMPNN safe to use?
- It is Apache-2.0-licensed and scores 100/100 on trust signals. Skills are instructions an agent will follow, so read the file before installing it and do not approve commands you do not understand.
- Is SolubleMPNN still maintained?
- The repository was last updated 2 days ago, so SolubleMPNN is actively maintained.
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Trust signals
From repository metadata: license, adoption, age and documentation. Not a code audit — see the Safety scan above for what the skill file itself contains.