MoaBox

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A repository of compound-target annotations in support of Systematic Chemogenetic Library Assembly

Supplementary materials to accompany bioRxiv preprint manuscript Systematic Chemogenetic Library Assembly

Copyright

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Abstract

The assembly of chemogenetic libraries composed of chemical probes provides tremendous value to biomedical research, but requires substantial effort to ensure diversity as well as quality of the contents. We are assembling a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our methodology, lessons learned, and disclosing our current collection of 4186 compounds with their primary annotated gene targets.

Authors

Stephen M. Canham^1*, Yuan Wang¹, Allen Cornett¹, Douglas S. Auld^1*, Daniel K. Baeschlin², Maude Patoor², Philip R. Skaanderup², Ayako Honda¹, Luis Llamas¹, Greg Wendel¹, Felipa A. Mapa¹, Peter Aspesi Jr. ¹, Nancy Labbe-Giguere¹, Gabriel G. Gamber1, Daniel S. Palacios¹, Ansgar Schuffenhauer², Zhan Deng¹, Florian Nigsch², Mathias Frederiksen², Simon M. Bushell¹, Deborah Rothman¹, Rishi K. Jain¹, Horst Hemmerle¹, Karin Briner¹, Jeffery A. Porter¹, John A. Tallarico¹, Jeremy L. Jenkins^1*

¹ Novartis Institute for BioMedical Research, 181 Massachusetts Ave Cambridge, MA 02139

² Novartis Institute for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland

^*e-mail: steve.canham@novartis.com; douglas.auld@novartis.com; jeremy.jenkins@novartis.com