7,254 skills found · Page 4 of 242
osm-search / NominatimOpen Source search based on OpenStreetMap data
nucleuscloud / NeosyncOpen Source Data Security Platform for Developers to Monitor and Detect PII, Anonymize Production Data and Sync it across environments.
opensourcepos / OpensourceposOpen Source Point of Sale is a web based point of sale application written in PHP using CodeIgniter framework. It uses MySQL as the data back end and has a Bootstrap 3 based user interface. If you like this project, please give it a star! Doing so helps maintain Popular OSS status for the project.
deepchecks / DeepchecksDeepchecks: Tests for Continuous Validation of ML Models & Data. Deepchecks is a holistic open-source solution for all of your AI & ML validation needs, enabling to thoroughly test your data and models from research to production.
electricitymaps / Electricitymaps ContribThe open source repository for Electricity Maps data parsers that powers the world's most comprehensive electricity data platform
nkaz001 / HftbacktestFree, open source, a high frequency trading and market making backtesting and trading bot, which accounts for limit orders, queue positions, and latencies, utilizing full tick data for trades and order books(Level-2 and Level-3), with real-world crypto trading examples for Binance and Bybit
Findomain / FindomainThe fastest and complete solution for domain recognition. Supports screenshoting, port scan, HTTP check, data import from other tools, subdomain monitoring, alerts via Discord, Slack and Telegram, multiple API Keys for sources and much more.
linkedin / DatabusSource-agnostic distributed change data capture system
EBazarov / Nsfw Data Source UrlsCollection of NSFW images URLs for the purposes of training an NSFW Image Classifier
nullptrlabs / PgmodelerOpen-source data modeling tool designed for PostgreSQL. No more typing DDL commands. Let pgModeler do the work for you!
AutoFixture / AutoFixtureAutoFixture is an open source library for .NET designed to minimize the 'Arrange' phase of your unit tests in order to maximize maintainability. Its primary goal is to allow developers to focus on what is being tested rather than how to setup the test scenario, by making it easier to create object graphs containing test data.
AmrDeveloper / GQLGitQL is a extensible SQL-like query language and SDK to perform queries on various data sources such .git files with supports of most of SQL features such as grouping, ordering and aggregation and window functions and allow customization like user-defined types and functions
sugarforever / Chat OllamaChatOllama is an open-source AI chatbot that brings cutting-edge language models to your fingertips while keeping your data private and secure.
NAalytics / Assemblies Of Putative SARS CoV2 Spike Encoding MRNA Sequences For Vaccines BNT 162b2 And MRNA 1273RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.
rbhatia46 / Data Science Interview ResourcesA repository listing out the potential sources which will help you in preparing for a Data Science/Machine Learning interview. New resources added frequently.
deta / SurfPersonal AI Notebooks. Organize files & webpages and generate notes from them. Open source, local & open data, open model choice (incl. local).
pydata / Pandas DatareaderExtract data from a wide range of Internet sources into a pandas DataFrame.
gunnarmorling / Awesome Opensource Data EngineeringAn Awesome List of Open-Source Data Engineering Projects
RxSwiftCommunity / RxDataSourcesUITableView and UICollectionView Data Sources for RxSwift (sections, animated updates, editing ...)
SolaceLabs / Solace Agent MeshAn event-driven framework designed to build and orchestrate multi-agent AI systems. It enables seamless integration of AI agents with real-world data sources and systems, facilitating complex, multi-step workflows.
